Ethyl oxamate → HCID 135705331、化合物

HRID 442213ノート

反応式

HRID 442213 の反応式
[NH2:1][C:2]1[C:11]([C:12]([NH2:14])=[O:13])=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[C:15](OCC)(=O)[C:16]([NH2:18])=[O:17].C[O-].[Na+]>C(O)CO>[N:1]1[C:2]2=[N:3][C:4]3[C:9]([CH:10]=[C:11]2[C:12](=[O:13])[NH:14][C:15]=1[C:16]([NH2:18])=[O:17])=[CH:8][CH:7]=[CH:6][CH:5]=3

参加物

5

反応物 3

HCID 69238Ethyl oxamateHCID 52002282-Amino-3-quinolinecarboxamideHCID 10942334Sodium Methoxide

生成物 1

HCID 135705331HCID 135705331、化合物

試薬・触媒・溶媒 1

HCID 174Ethylene Glycol溶媒

反応条件

温度
170 °C

実験手順

A mixture of 2-aminoquinoline-3-carboxamide (2.0 g., 1.15 millimoles) ethyl oxamate (2.71 g., 23.1 millimoles), ethylene glycol (10 ml.) and sodium methoxide (10 mg.) is heated at 170° C. for 1 hour. The product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture followed by chilling in an ice bath. It is filtered off, washed with cold methanol and dried in vacuo. Yield = 0.768 g. (28%). M.P. 320° C.

後処理

  1. customThe product is precipitated by slow addition of ice cold methanol (50 ml.) to the hot reaction mixture
  2. temperatureby chilling in an ice bath
  3. filtrationIt is filtered off
  4. washwashed with cold methanol
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-55ac4ce680434f528859486b19e42471
出典データセット
uspto-grants-1977_08
特許番号
US04044134

反応ノート

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