1,3-Dibromopropane → N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane

HRID 442222ノート

反応式

HRID 442222 の反応式
[C:1](=[O:4])([O-])[O-].[K+].[K+].[CH3:7][NH:8][CH2:9][CH2:10][CH2:11][OH:12].Br[CH2:14][CH2:15][CH2:16]Br>C(O)C>[CH3:7][N:8]([CH2:9][CH2:10][CH2:1][OH:4])[CH2:14][CH2:15][CH2:16][N:8]([CH3:7])[CH2:9][CH2:10][CH2:11][OH:12]

参加物

5

反応物 3

HCID 80011,3-DibromopropaneHCID 11430Potassium CarbonateHCID 101489863-(Methylamino)-1-propanol

生成物 1

HCID 12721803N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane収率 55.5%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

15 g of anhydrous potassium carbonate are added to a solution of 9 g of 3-methylaminopropanol and 10 g of 1,3-dibromopropane in 100 ml of ethanol, and the reaction mixture is stirred and refluxed for 24 hours. The mixture is allowed to cool, filtered, the filtrate is evaporated, and the residue is distilled. 6 g of N,N'-dimethyl-N,N'-bis(3-hydroxypropyl)-1,3-diaminopropane are obtained; b.p.: 150°-154° C/2 mmHg, nD20 = 1.4793.

後処理

  1. temperaturerefluxed for 24 hours
  2. temperatureto cool
  3. filtrationfiltered
  4. customthe filtrate is evaporated
  5. distillationthe residue is distilled

出典と根拠

ORDレコード
ord-b6f9df485a2c4b1e8434697c003d3d95
出典データセット
uspto-grants-1977_08
特許番号
US04044146

反応ノート

読み込み中…