4'-Fluoro-2'-methoxy-4-nitrobiphenyl → 4'-Fluoro-2'-methoxy[1,1'-biphenyl]-4-amine
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][CH:9]=2)=[C:4]([O:17][CH3:18])[CH:3]=1.[H][H]>[Pd].C(O)C>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([NH2:14])=[CH:10][CH:9]=2)=[C:4]([O:17][CH3:18])[CH:3]=1参加物
5
実験手順
A mixture of 10 grams of 4'-fluoro-2'-methoxy-4-nitrobiphenyl in 250 ml. of ethanol is reduced by hydrogen at atmospheric pressure and at room temperature using 5% palladium-on-charcoal (0.5 gram) catalyst. After the required uptake of hydrogen, the mixture is filtered and the catalyst washed with fresh ethanol. The ethanol solution is then concentrated in vacuo, and the residue recrystallized from aqueous ethanol to yield 4-(4'-fluoro-2'-methoxyphenyl)-aniline.
後処理
- filtrationAfter the required uptake of hydrogen, the mixture is filtered
- washthe catalyst washed with fresh ethanol
- concentrationThe ethanol solution is then concentrated in vacuo
- customthe residue recrystallized from aqueous ethanol
出典と根拠
- ORDレコード
- ord-b68a5fb89a654044a40c3a10d2f81774
- 出典データセット
- uspto-grants-1977_08
- 特許番号
- US04044049
反応ノート
読み込み中…