3'-Aminoacetophenone → HCID 53797596、化合物
反応式
[NH2:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[C:11]([C:16]1[CH:26]=[C:25]([C:27]([CH2:30][CH3:31])([CH3:29])[CH3:28])[CH:24]=[CH:23][C:17]=1[O:18][CH2:19][C:20](Cl)=[O:21])([CH2:14][CH3:15])([CH3:13])[CH3:12]>N1C=CC=CC=1>[C:11]([C:16]1[CH:26]=[C:25]([C:27]([CH2:30][CH3:31])([CH3:29])[CH3:28])[CH:24]=[CH:23][C:17]=1[O:18][CH2:19][C:20]([NH:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1)=[O:21])([CH2:14][CH3:15])([CH3:13])[CH3:12]参加物
4
実験手順
40 grams (0.1 mol) of N-α -(2,4-di-tert-amylphenoxy)acetyl-m-aminoacetophenone (m.p.:135° C), obtained by the reaction between m-aminoacetophenone and α-(2,4-di-tert-amylphenoxy)acetyl chloride in pyridine, was dissolved in 200 ml of anhydrous ethyl ether (placed in a three-necked flask), and 0.5 g of anhydrous aluminum chloride powder was added to this solution followed by ice-cooling (about 0°-5° C.) under stirring. 16 grams (0.1 mol) of bromine was added dropwise to this mixture. After the completion of the dropwise addition, the temperature was allowed to rise to room temperature (about 20°-35° C.). Stirring was continued until the generation of hydrogen bromide stopped. Thus, white crystals were precipitated.