2-Amino-2-methyl-1,3-propanediol → HCID 21414467、化合物
反応式
[CH:1]1([C:7]#[N:8])[CH2:4][CH2:3][CH:2]1[C:5]#[N:6].[OH:9][CH2:10][C:11](N)([CH3:14])[CH2:12][OH:13]>Cl[Cu]>[CH3:14][C:11]1([CH2:12][OH:13])[CH2:10][O:9][C:5]([CH:2]2[CH2:3][CH2:4][CH:1]2[C:7]2[O:9][CH2:10][C:11]([CH2:12][OH:13])([CH3:14])[N:8]=2)=[N:6]1参加物
4
実験手順
53 g of cyclobutane-1,2-dinitrile were heated for 3.5 hours to 100° C. with 150 g of 2-hydroxymethyl-2-amino-1-propanol in the presence of 0.5 g of CuCl. Distillation of the reaction mixture in the same way as described in Example 15 gave 175 g of distillate boiling (79)C./142° - 200° C/0.6 Torr which, when subsequently fractionated in a Vigreux column, gave 117 g (83% of the theoretical) of 1,2-bis-(4-methyl-4-hydroxymethyl oxazolin-2-yl)-cyclobutane boiling at 198° - 204° C./0.05 Torr.
後処理
- distillationDistillation of the reaction mixture in the same way
- customgave 175 g of distillate
- custom142° - 200° C/0.6 Torr which, when
出典と根拠
- ORDレコード
- ord-2461c34a4cba481196e7d5d0515e5046
- 出典データセット
- uspto-grants-1977_08
- 特許番号
- US04045447
反応ノート
読み込み中…