Benzene → 2-Cyclohexen-1-one, 2,6,6-trimethyl-3-(2-methylpropoxy)-

HRID 442404ノート

反応式

HRID 442404 の反応式
[CH3:1][CH:2]1[C:7](=[O:8])[CH:6]=[CH:5][C:4]([CH3:10])([CH3:9])[C:3]1=[O:11].C1C=CC=CC=1.[CH2:18](O)[CH:19]([CH3:21])[CH3:20].CC1C=CC(S(O)(=O)=O)=CC=1>O>[CH3:1][C:2]1[C:3](=[O:11])[C:4]([CH3:10])([CH3:9])[CH2:5][CH2:6][C:7]=1[O:8][CH2:18][CH:19]([CH3:21])[CH3:20]

参加物

6

反応物 4

HCID 241BenzeneHCID 6101p-Toluenesulfonic acidHCID 6560IsobutanolHCID 70585111HCID 70585111、化合物

生成物 1

HCID 109217652-Cyclohexen-1-one, 2,6,6-trimethyl-3-(2-methylpropoxy)-

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

The compound 2,6,6-trimethylcyclohexen-1,3-dione (43.6 g) was added to a mixture of benzene (250 ml), isobutanol (50 ml) and PTSA (500 mg) and heated under reflux for 3 hr in conjunction with a Dean and Stark water separator. The reaction was then cooled to room tmperature, washed with aqueous sodium carbonate solution and brine and taken to dryness in vacuo. Distillation of residue through a 6 inch vacuum jacketed vigreaux column yielded pure 2,6,6-trimethyl-3-isobutoxycyclohex-2-en-1 one (54.6 g) b p 104°-107°.

後処理

  1. temperatureheated
  2. temperatureThe reaction was then cooled to room tmperature
  3. washwashed with aqueous sodium carbonate solution and brine
  4. distillationDistillation of residue through a 6 inch vacuum

出典と根拠

ORDレコード
ord-c2ae4c8be01c44ea893f691f36e91e81
出典データセット
uspto-grants-1977_08
特許番号
US04045476

反応ノート

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