p-Toluenesulfonic acid → 1,1,3,3-Tetramethylindan-5-ol

HRID 442474

反応式

HRID 442474 の反応式
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].O[C:13]1[CH:18]=CC(C(C2C=CC(O)=CC=2)(C)C)=C[CH:14]=1.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[OH:11][C:8]1[CH:7]=[C:6]2[C:5](=[CH:10][CH:9]=1)[C:1]([CH3:4])([CH3:2])[CH2:3][C:13]2([CH3:18])[CH3:14]

参加物

4

反応物 3

HCID 6101p-Toluenesulfonic acidHCID 6623Bisphenol AHCID 73934-tert-Butylphenol

生成物 1

HCID 1045671,1,3,3-Tetramethylindan-5-ol収率 19.9%

実験手順

172.5 g of 4-tert.-butylphenol, 57.5 g of 2,2-bis-(4-hydroxyphenyl)-propane and 20 g of p-toluene sulphonic acid are stirred in an autoclave for 6 hours at around 180° C. After cooling, the reaction mixture is repeatedly washed with about 250 ml of 10 % by weight aqueous sodium hydrogen carbonate solution to remove the catalyst, and then subjected to fractional distillation in vacuo. 9.3 g (0.05 mol) of 5-hydroxy-1,1,3,3-tetramethyl indane are isolated from 157.7 g of reaction mixture.

後処理

  1. temperatureAfter cooling
  2. washthe reaction mixture is repeatedly washed with about 250 ml of 10 % by weight aqueous sodium hydrogen carbonate solution
  3. customto remove the catalyst
  4. distillationsubjected to fractional distillation in vacuo

出典と根拠

ORDレコード
ord-860c3af05d6748d7bad68e212ccd9fd7
出典データセット
uspto-grants-1977_08
特許番号
US04045499

関連ノート

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