Sodium borohydride → 1-[4-Hydroxy-4-(4-chlorophenyl)butyl]imidazole

HRID 442510ノート

反応式

HRID 442510 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8](=[O:17])[CH2:9][CH2:10][CH2:11][N:12]2[CH:16]=[CH:15][N:14]=[CH:13]2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[OH:17][CH:8]([C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:9][CH2:10][CH2:11][N:12]1[CH:16]=[CH:15][N:14]=[CH:13]1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 190783351-[4-(4-Chlorophenyl)butan-4-onyl]imidazole

生成物 1

HCID 203652141-[4-Hydroxy-4-(4-chlorophenyl)butyl]imidazole

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a 0° C. solution of 5 g. of the above ketone in 150 ml. of anhydrous methanol was added excess sodium borohydride, and the mixture stirred for 1 hour. After removal of the solvent, a small quantity of water was added and the mixture was extracted with ethyl acetate. The combined extracts were dried over magnesium sulfate and evaporated to afford 1-[4-hydroxy-4-(4-chlorophenyl)butyl]imidazole.

後処理

  1. customTo a 0° C.
  2. customAfter removal of the solvent
  3. additiona small quantity of water was added
  4. extractionthe mixture was extracted with ethyl acetate
  5. dry with materialThe combined extracts were dried over magnesium sulfate
  6. customevaporated

出典と根拠

ORDレコード
ord-a9be0da4478146a18dbc13aa49ae9732
出典データセット
uspto-grants-1977_08
特許番号
US04045568

反応ノート

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