Sodium Hydroxide → Amfenac

HRID 442545

反応式

HRID 442545 の反応式
[C:1]([C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[NH:16][C:15](=[O:18])[CH2:14]2)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:19].[Na+]>>[NH2:16][C:17]1[C:9]([C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:10][CH:11]=[CH:12][C:13]=1[CH2:14][C:15]([OH:18])=[O:19]

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 1709837-Benzoyl-2-oxindole

生成物 1

HCID 2136Amfenac

実験手順

A mixture of 1.0 g. (0.004 mole) of 7-benzoylindolin-2-one was added to 30 ml. of 3N sodium hydroxide and the basic solution was refluxed for 45 minutes under nitrogen. The mixture was filtered and the filtrate was neutralized with glacial acetic acid. The precipitate was filtered off, washed with water and dried. The material melted at 122° C. (dec.). The yield was 0.8 g. (72%).

後処理

  1. additionA mixture of 1.0 g
  2. filtrationThe mixture was filtered
  3. filtrationThe precipitate was filtered off
  4. washwashed with water
  5. customdried

出典と根拠

ORDレコード
ord-d13b5b9f6e454e5198c7607b2243951d
出典データセット
uspto-grants-1977_08
特許番号
US04045576

関連ノート

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