Sodium Hydroxide → Sodium 2-amino-3-benzoyl-alpha-methylphenylacetate Hydrate

HRID 442553

反応式

HRID 442553 の反応式
[C:1]([C:9]1[CH:10]=[CH:11][CH:12]=[C:13]2[C:17]=1[NH:16][C:15](=[O:18])[CH:14]2[CH3:19])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-:20].[Na+:21]>O>[OH2:8].[NH2:16][C:17]1[C:9]([C:1](=[O:8])[C:2]2[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=2)=[CH:10][CH:11]=[CH:12][C:13]=1[CH:14]([CH3:19])[C:15]([O-:20])=[O:18].[Na+:21]

参加物

4

反応物 2

HCID 14798Sodium Hydroxide2 回HCID 129012437-Benzoyl-3-methyl-1,3-dihydro-2H-indol-2-one

生成物 1

HCID 70591625Sodium 2-amino-3-benzoyl-alpha-methylphenylacetate Hydrate

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A suspension of 9 g. (0.036 mole) of 7-benzoyl-3-methylindolin-2-one in 100 ml. of 3N sodium hydroxide was refluxed for 18 hrs. under nitrogen. The mixture was filtered and stripped under water pump vacuum to yield a gummy mixture of sodium hydroxide, water, and product. The mixture was triturated with boiling isopropanol and filtered. The isopropanol solution was cooled and filtered to separate the bright yellow product. The product weighed 4.0 g. and melted at 218° C. (dec.)

後処理

  1. additionA suspension of 9 g
  2. filtrationThe mixture was filtered
  3. customto yield
  4. customThe mixture was triturated with boiling isopropanol
  5. filtrationfiltered
  6. temperatureThe isopropanol solution was cooled
  7. filtrationfiltered
  8. customto separate the bright yellow product

出典と根拠

ORDレコード
ord-6763f917c09b4e4bbd1a9ceb3e1d99ed
出典データセット
uspto-grants-1977_08
特許番号
US04045576

関連ノート

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