Hydrogen Peroxide → (S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile

HRID 442587ノート

反応式

HRID 442587 の反応式
[C:1]([C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C@@H:11]([CH3:14])[CH2:12][CH3:13])#[N:2].[OH:18]O>C1COCC1>[OH:18][C:5]1[CH:6]=[CH:7][C:8]([O:9][CH2:10][C@@H:11]([CH3:14])[CH2:12][CH3:13])=[C:3]([CH:4]=1)[C:1]#[N:2]

参加物

4

反応物 2

HCID 784Hydrogen PeroxideHCID 53923893(S)-(+)-3-Cyano-4-(2-methylbutyloxy)phenylboronic acid

生成物 1

HCID 54230638(S)-(+)-5-Hydroxy-2-(2-methylbutyloxy)benzonitrile

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A mixture of compound 47 (3.00 g, 0.014 mol), hydrogen peroxide (30% w/v, 150 ml) and THF (200 ml) was heated under reflux for 3 h. The water/THF mixture was removed in vacuo and the oily residue was dissolved in diethyl ether and washed with water. The ether was dried (MgSO4) and evaporated in vacuo to give a viscous, fawn oil.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 3 h
  3. customThe water/THF mixture was removed in vacuo
  4. dissolutionthe oily residue was dissolved in diethyl ether
  5. washwashed with water
  6. dry with materialThe ether was dried (MgSO4)
  7. customevaporated in vacuo
  8. customto give a viscous, fawn oil

出典と根拠

ORDレコード
ord-b70419c29651497088e7b132a6d6efe6
出典データセット
uspto-grants-1999_04
特許番号
US05891358

反応ノート

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