Hydrochloric Acid → 4'-Nonanoyloxybiphenyl-4-carboxylic acid

HRID 442594

反応式

HRID 442594 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.[C:17](Cl)(=[O:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25].CN(C1C=CC=CN=1)C.Cl>ClCCl.C(N(CC)CC)C>[C:17]([O:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([OH:16])=[O:15])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1)(=[O:26])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 218852-DimethylaminopyridineHCID 69819Nonanoyl chlorideHCID 3015564'-Hydroxy-4-biphenylcarboxylic acid

生成物 1

HCID 136684514'-Nonanoyloxybiphenyl-4-carboxylic acid収率 86.3%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 8471Triethylamine溶媒

実験手順

4'-Hydroxybiphenyl-4-carboxylic acid (3.5 g) and triethylamine (2.4 g) were dissolved in dichloromethane (30 ml). Nonanoyl chloride (4.3 g) and dimethylaminopyridine (0.2 g) were added to the solution, and the mixture was stirred at room temperature for about 20 hours. Dilute hydrochloric acid was added thereto, and the organic layer was separated in a separating funnel. The solvent was removed by evaportaion, and the residue was dried after washing with n-hexane to give the titled compound (5 g).

後処理

  1. customthe organic layer was separated in a separating funnel
  2. customThe solvent was removed by evaportaion
  3. customthe residue was dried
  4. washafter washing with n-hexane

出典と根拠

ORDレコード
ord-0fbb1e06db2441929e7b81c2113f4d94
出典データセット
uspto-grants-1999_04
特許番号
US05891359

関連ノート

読み込み中…