Piperazine → HCID 54471836、化合物

HRID 442704

反応式

HRID 442704 の反応式
[O:1]1[CH:3]([CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:2]1.[NH:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1.C(=O)([O-])[O-].[K+].[K+].C(Cl)(Cl)Cl>CN(C)C=O>[OH:1][CH:3]([CH2:4][O:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH3:23])[CH2:2][N:24]1[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]1

参加物

6

反応物 4

HCID 4837PiperazineHCID 6212ChloroformHCID 11430Potassium CarbonateHCID 61831Oxirane, 2-[(octadecyloxy)methyl]-

生成物 1

HCID 54471836HCID 54471836、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1,2-Epoxy-3-octadecyloxypropane (5.0 g, 15.3 mmol) is added to a mixture of piperazine (1.94 g, 22.5 mmol) and anhydrous potassium carbonate (100 mg) in dimethyl formamide (60 mL) over a 30 minute period under a nitrogen atmosphere. The resultant mixture is stirred at 80°-90° C. (oil bath temperature) for 48 hours. The reaction mixture is cooled to room temperature and concentrated in vacuo to leave a residue. The residue is stirred with chloroform (125 mL). The undissolved material is filtered in vacuo, and the filtrate is concentrated in vacuo, purified by chromatography and dried in vacuo to afford 1-[2'-hydroxy-3'-octadecyloxypropyl]-piperazine.

後処理

  1. concentrationconcentrated in vacuo
  2. customto leave a residue
  3. filtrationThe undissolved material is filtered in vacuo
  4. concentrationthe filtrate is concentrated in vacuo
  5. custompurified by chromatography
  6. customdried in vacuo

出典と根拠

ORDレコード
ord-5c6efe180eae410283b11c8a74baa6f1
出典データセット
uspto-grants-1999_04
特許番号
US05891881

関連ノート

読み込み中…