Monoethyl malonate → Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

HRID 442797

反応式

HRID 442797 の反応式
[CH3:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4](Cl)=[O:5].[Li][Li].[C:14]([O:20][CH2:21][CH3:22])(=[O:19])[CH2:15]C(O)=O>>[CH3:1][C:2]1[CH:10]=[C:9]([Br:11])[CH:8]=[CH:7][C:3]=1[C:4]([CH2:15][C:14]([O:20][CH2:21][CH3:22])=[O:19])=[O:5]

参加物

4

反応物 3

HCID 70615Monoethyl malonateHCID 139759Lithium, mol. (Li2)HCID 128464834-Bromo-2-methylbenzoyl chloride

生成物 1

HCID 53404613Ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

実験手順

2-Methyl-4-bromobenzoyl chloride (29.1 g, 0.13 mol) was treated with the dilithium salt of ethyl hydrogen malonate (28.0 g, 0.21 mol) and the product was isolated by the procedure described in Example 1 (ii). The crude product was purified on flash silica, eluting with dichloromethane-hexane (1:1 then 3:2) to give ethyl 2-methyl-4-bromobenzoylacetate as an oil.

後処理

  1. customthe product was isolated by the procedure
  2. customThe crude product was purified on flash silica
  3. washeluting with dichloromethane-hexane (1:1

出典と根拠

ORDレコード
ord-ddc09ecaf6e64ae8b211449d5c77514a
出典データセット
uspto-grants-1999_04
特許番号
US05891899

関連ノート

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