4,4'-Dichlorobenzhydrol → Ethyl 3-[bis(4-chlorophenyl)methyl]indole-2-carboxylate

HRID 442882

反応式

HRID 442882 の反応式
[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6](O)[C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[NH:17]1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[CH:19]=[C:18]1[C:26]([O:28][CH2:29][CH3:30])=[O:27]>>[Cl:1][C:2]1[CH:16]=[CH:15][C:5]([CH:6]([C:7]2[CH:12]=[CH:11][C:10]([Cl:13])=[CH:9][CH:8]=2)[C:19]2[C:20]3[C:25](=[CH:24][CH:23]=[CH:22][CH:21]=3)[NH:17][C:18]=2[C:26]([O:28][CH2:29][CH3:30])=[O:27])=[CH:4][CH:3]=1

参加物

3

反応物 2

HCID 70334,4'-DichlorobenzhydrolHCID 73125Ethyl indole-2-carboxylate

生成物 1

HCID 67594252Ethyl 3-[bis(4-chlorophenyl)methyl]indole-2-carboxylate収率 94%

実験手順

Substantially the same procedure as in Reference Example 5 was repeated using 4,4'-dichlorobenzhydrol (14.7 g, 58.1 mmol) and ethyl indole-2-carboxylate (10.0 g, 52.9 mmol) to give 21.0 g (yield: 94%) of the title compound.

出典と根拠

ORDレコード
ord-a6fbd53ca08949f6ae276da5c97adfec
出典データセット
uspto-grants-1999_04
特許番号
US05891902

関連ノート

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