1,1'-Carbonyldiimidazole → 3-[2-(4-Nitro-phenyl)-ethyl]-oxazolidin-2-one

HRID 44294ノート

反応式

HRID 44294 の反応式
C1N=CN([C:6](N2C=NC=C2)=[O:7])C=1.[N+:13]([C:16]1[CH:21]=[CH:20][C:19]([CH2:22][CH2:23][NH:24][CH2:25][CH2:26][OH:27])=[CH:18][CH:17]=1)([O-:15])=[O:14]>CN(C1C=CN=CC=1)C.C(Cl)Cl>[N+:13]([C:16]1[CH:17]=[CH:18][C:19]([CH2:22][CH2:23][N:24]2[CH2:25][CH2:26][O:27][C:6]2=[O:7])=[CH:20][CH:21]=1)([O-:15])=[O:14]

参加物

5

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 227227442-[2-(4-Nitro-phenyl)-ethylamino]-ethanol

生成物 1

HCID 107761683-[2-(4-Nitro-phenyl)-ethyl]-oxazolidin-2-one

試薬・触媒・溶媒 2

HCID 142844-(Dimethylamino)pyridine触媒HCID 6344Dichloromethane溶媒2 回

実験手順

CDI (89 mmoles) is added to a solution of the compound obtained in Step A (44.5 mmoles) and DMAP (44.5 mmoles) in DCM (250 ml). After stirring for 4 hours at ambient temperature, the reaction mixture is diluted with 300 ml of DCM and then washed with 2M HCl solution (5×200 ml). The organic phase is dried over magnesium sulphate, filtered and evaporated to dryness to yield the title product in the form of an orange solid, which is used directly in the next Step.

後処理

  1. washwashed with 2M HCl solution (5×200 ml)
  2. dry with materialThe organic phase is dried over magnesium sulphate
  3. filtrationfiltered
  4. customevaporated to dryness

出典と根拠

ORDレコード
ord-485569c2c3f14abdb864fbf672676ab1
出典データセット
uspto-grants-2013_09
特許番号
US08541412B2

反応ノート

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