Hydrazinecarboxaldehyde → 6-(3-Pyridinyl)-1,2,4-triazolo[4,3-b]pyridazine

HRID 443512

反応式

HRID 443512 の反応式
Cl[C:2]1[N:3]=[N:4][C:5]([C:8]2[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=2)=[CH:6][CH:7]=1.[CH:14]([NH:16][NH2:17])=O>C(O)CCC>[N:10]1[CH:11]=[CH:12][CH:13]=[C:8]([C:5]2[CH:6]=[CH:7][C:2]3[N:3]([CH:14]=[N:16][N:17]=3)[N:4]=2)[CH:9]=1

参加物

4

反応物 2

HCID 12229HydrazinecarboxaldehydeHCID 167324353-Chloro-6-(pyridin-3-yl)pyridazine

生成物 1

HCID 142879776-(3-Pyridinyl)-1,2,4-triazolo[4,3-b]pyridazine

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

A mixture of 1.5 g. of 3-chloro-6-(3-pyridyl)pyridazine and 0.96 g. of formic acid hydrazide in 50 ml. of n-butyl alcohol is refluxed for 48 hours. The reaction mixture is concentrated, partitioned and crystallized as described in Example 1 to afford 1.0 g. of the product of the Example as a cream colored solid, m.p. 199°-200°.

後処理

  1. additionA mixture of 1.5 g
  2. concentrationThe reaction mixture is concentrated
  3. custompartitioned
  4. customcrystallized
  5. customto afford 1.0 g

出典と根拠

ORDレコード
ord-8179f5fda6934fe5921f263e191122e3
出典データセット
uspto-grants-1981_04
特許番号
US04260756

関連ノート

読み込み中…