Acetohydrazide → HCID 23467590、化合物

HRID 443516ノート

反応式

HRID 443516 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH2:7][CH2:8][C:9](=O)[NH:10][N:11]=1.Cl[C:14]1[N:15]=[N:16]C(C2OC=CC=2)=C[CH:19]=1.C(NN)(=O)C>C(O)CCC>[CH3:19][C:14]1[N:10]2[N:11]=[C:6]([C:2]3[O:1][CH:5]=[CH:4][CH:3]=3)[CH:7]=[CH:8][C:9]2=[N:16][N:15]=1

参加物

5

反応物 3

HCID 14039AcetohydrazideHCID 234675803-Chloro-6-(2-furanyl)pyridazineHCID 54470727HCID 54470727、化合物

生成物 1

HCID 23467590HCID 23467590、化合物

試薬・触媒・溶媒 1

HCID 2631-Butanol溶媒

実験手順

As for Example 5, 4,5-dihydro-6-(2-furyl)-3(2H)-pyridazinone is converted to 3-chloro-6-(2-furyl)pyridazine. A 1.5 g. sample of the preceding compound, 1.2 g. of acethydrazide in 50 ml. of n-butyl alcohol is refluxed for 48 hours. The solvent is removed under reduced pressure and the residue is partitioned between dichloromethane and dilute sodium hydroxide. The dichloromethane layer is washed with water, dried over magnesium sulfate, filtered and concentrated. The residue is purified by conventional means to give the product of the Example.

後処理

  1. customThe solvent is removed under reduced pressure
  2. customthe residue is partitioned between dichloromethane and dilute sodium hydroxide
  3. washThe dichloromethane layer is washed with water
  4. dry with materialdried over magnesium sulfate
  5. filtrationfiltered
  6. concentrationconcentrated
  7. customThe residue is purified by conventional means
  8. customto give the product of the Example

出典と根拠

ORDレコード
ord-9a4accac960040f7bcdc01000eb6a2ad
出典データセット
uspto-grants-1981_04
特許番号
US04260756

反応ノート

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