Acetic acid, 2-(triphenylphosphoranylidene)-, methyl ester → 2-(1-Benzofuran-2-yl)acetic acid

HRID 443564

反応式

HRID 443564 の反応式
[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3](=O)[CH2:2]1.[C:11]([CH:15]=P(C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)([O:13]C)=[O:12]>C1(C)C=CC=CC=1>[O:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[CH2:15][C:11]([OH:13])=[O:12]

参加物

4

反応物 2

HCID 17453Acetic acid, 2-(triphenylphosphoranylidene)-, methyl esterHCID 23556Coumaranone

生成物 1

HCID 111058882-(1-Benzofuran-2-yl)acetic acid収率 94.6%

試薬・触媒・溶媒 1

HCID 1140Toluene溶媒

実験手順

A mixture of 71.1 g of 3-benzofuranone [D. C. Schroeder, P. O. Corcoran, C. A. Holden, and M. C. Mulligan, J. Org. Chem., 27, 586 (1962)], 210 g of carbomethoxymethylenetriphenylphosphorane and 300 ml of toluene was heated under reflux for 8 hours. The solvent was removed and the residue stirred with ether and filtered. The filtrate was concentrated and the residue heated under reflux with 300 ml of methanol and 300 ml of 15% sodium hydroxide solution for 2 hours. The cooled mixture was diluted with water and extracted several times with methylene chloride. Acidification of the water layer and extraction with methylene chloride gave 88.3 g of crude 3-benzofuranacetic acid. The product was dissolved in 500 ml of tetrahydrofuran, and 50 g of borane-methyl sulfide complex added. After stirring at room temperature overnight, the excess reagent was destroyed by slow addition of 100 ml of conc. hydrochloric acid. The mixture was made basic and extracted several times with methylene chloride and the product shortpath distilled (bath temperature) 110°, 1 micron pressure) to give 65.8 g (76%) of 3-benzofuranethanol. NMR spectrum (in CDCl3): τ2.3-3.0 (m, 5); 6.2 (t, J=6 Hz, 2) 7.1 (t, J=6 Hz, 2) and 7.3 (s, 1).

後処理

  1. temperatureunder reflux for 8 hours
  2. customThe solvent was removed
  3. filtrationfiltered
  4. concentrationThe filtrate was concentrated
  5. temperaturethe residue heated
  6. temperatureunder reflux with 300 ml of methanol and 300 ml of 15% sodium hydroxide solution for 2 hours
  7. additionThe cooled mixture was diluted with water
  8. extractionextracted several times with methylene chloride
  9. extractionAcidification of the water layer and extraction with methylene chloride

出典と根拠

ORDレコード
ord-996a8fd5330641919ed57ec530f541bd
出典データセット
uspto-grants-1981_04
特許番号
US04260761

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