Sodium borohydride → 5-Chloro-2'-fluoro-2-iodobenzhydrol

HRID 443578ノート

反応式

HRID 443578 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:17])=[C:6]([CH:16]=1)[C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15])=[O:8].[BH4-].[Na+]>C(O)C.O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([I:17])=[C:6]([CH:16]=1)[CH:7]([OH:8])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[F:15]

参加物

5

反応物 2

HCID 4311764Sodium borohydrideHCID 12948263(5-Chloro-2-iodophenyl)(2-fluorophenyl)methanone

生成物 1

HCID 205631225-Chloro-2'-fluoro-2-iodobenzhydrol

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 962Water溶媒

反応条件

温度
0 °C

実験手順

A mixture of 54 g (0.15 mole) of 5-chloro-2'-fluoro-2-iodobenzophenone and 28.4 g (0.75 mole) of sodium borohydride in 1000 ml of ethanol was stirred at 0° C. for 15 min. The solution was diluted with water and extracted with ether. The ether solution was washed with water, dried over anhydrous sodium sulfate, and concentrated at reduced pressure to give a deep yellow oil.

後処理

  1. extractionextracted with ether
  2. washThe ether solution was washed with water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated at reduced pressure
  5. customto give a deep yellow oil

出典と根拠

ORDレコード
ord-8f621fad600a4216a978b8e01061c24f
出典データセット
uspto-grants-1981_04
特許番号
US04260772

反応ノート

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