Ammonia → 2-Chloroquinazolin-4-amine
反応式
[Cl:1][C:2]1[N:11]=[C:10](Cl)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[NH3:13]>C1COCC1.CCOC(C)=O>[Cl:1][C:2]1[N:11]=[C:10]([NH2:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1参加物
5
実験手順
To a solution of 2,4-dichloroquinazoline (2.0 g, 10 mmol) in THF (10 mL), was added ammonia (28-30% in water, 18 mL). The reaction mixture was stirred at room temperature overnight. The reaction mixture was diluted with EtOAc, washed with saturated NaHCO3, water and brine, dried over Na2SO4, filtered and evaporated. The resulting solid was washed with EtOAc to give the title compound (1.3 g, 72%). 1H NMR (400 MHz, DMSO-d6) δ7.52-7.48 (m, 1H), 7.6-7.58 (m, 1H), 7.8-7.76 (m, 1H), 8.22-8.20 (m, 1H), 8.32 (bs, 2H).
後処理
- washwashed with saturated NaHCO3, water and brine
- dry with materialdried over Na2SO4
- filtrationfiltered
- customevaporated
- washThe resulting solid was washed with EtOAc
出典と根拠
- ORDレコード
- ord-0a687d3bfdb04c43b9ca57ac7844f968
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541421B2
反応ノート
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