HCID 178488043、化合物 → HCID 178524063、化合物

HRID 443822ノート

反応式

HRID 443822 の反応式
C[O:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1>Br.C(O)(=O)C.O>[OH:2][C:3]1[CH:12]=[CH:11][C:10]2[NH:9][C:8]3=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[N:15][N:7]3[C:6](=[O:19])[C:5]=2[CH:4]=1

参加物

5

反応物 1

HCID 178488043HCID 178488043、化合物

生成物 1

HCID 178524063HCID 178524063、化合物

試薬・触媒・溶媒 3

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒HCID 962Water溶媒

実験手順

A suspension of 4,9-dihydro-7-methoxy-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid (2.0 g; 0.0077 mole) in 48% hydrobromic acid (30 ml) and glacial acetic acid (50 ml) is refluxed for 23 hrs. The mixture is cooled and then diluted with water (25 ml). The product, which precipitates out, is collected by filtration and recrystallized from DMF-Ether (1:1, 90 ml). Yield 1.1 g; mp 285°-286° C. (d).

後処理

  1. temperatureis refluxed for 23 hrs
  2. temperatureThe mixture is cooled
  3. customThe product, which precipitates out
  4. filtrationis collected by filtration
  5. customrecrystallized from DMF-Ether (1:1, 90 ml)

出典と根拠

ORDレコード
ord-18fa4349312740089f5bb05920fe843a
出典データセット
uspto-grants-1981_04
特許番号
US04261996

反応ノート

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