Ammonium Chloride → 3-amino-4-chlorobenzophenone

HRID 443880ノート

反応式

HRID 443880 の反応式
[Cl-].[NH4+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])=[CH:6][C:5]=1[N+:18]([O-])=O>[Fe].CC1C=CC=CC=1>[NH2:18][C:5]1[CH:6]=[C:7]([C:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:11])[CH:8]=[CH:9][C:4]=1[Cl:3]

参加物

5

反応物 2

HCID 25517Ammonium ChlorideHCID 417434-Chloro-3-nitrobenzophenone

生成物 1

HCID 107995483-amino-4-chlorobenzophenone

試薬・触媒・溶媒 2

HCID 23925Iron触媒HCID 1140Toluene溶媒2 回

実験手順

To a stirred and refluxing mixture of 11.2 parts of iron, 100 parts of ammonium chloride solution 0.8 N and 20 parts of methylbenzene are added 10.5 parts of (4-chloro-3-nitrophenyl)phenylmethanone and the whole is further stirred at reflux temperature for one hour. Methylbenzene (80 parts) is added and the whole is filtered over Hyflo. The organic layer is separated, dried, filtered and evaporated. The residue is washed with cyclohexane, yielding 8.4 parts of (3-amino-4-chlorophenyl)phenylmethanone; mp. 91.9° C.

後処理

  1. temperaturerefluxing
  2. stirringthe whole is further stirred
  3. temperatureat reflux temperature for one hour
  4. filtrationthe whole is filtered over Hyflo
  5. customThe organic layer is separated
  6. customdried
  7. filtrationfiltered
  8. customevaporated
  9. washThe residue is washed with cyclohexane

出典と根拠

ORDレコード
ord-1a5f9a1f09d945a3b671efc624e16ff2
出典データセット
uspto-grants-1981_04
特許番号
US04262004

反応ノート

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