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Hydrochloric Acid → Boc-Tyr-(D)Ala-Gly-OBzl
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Ethylmorpholine | HCID 7525 | — |
| 反応物 | Isobutyl chloroformate | HCID 62365 | — |
| 反応物 | L-Tyrosine, N-(1,1-dimethylethoxy)carbonyl- | HCID 117439 | — |
| 反応物 | DAla-Gly-OBzl | HCID 12800382 | — |
| 反応物 | Boc-(D)Ala-Gly-OBzl | HCID 15567200 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | Boc-Tyr-(D)Ala-Gly-OBzl | HCID 15567201 | — |
反応手順
2.8 g of Boc-Tyr-OH and 1.3 ml of N-ethylmorpholine are dissolved in 50 ml of absolute tetrahydrofuran and 1.3 ml of chloroformic acid iso-butyl ester are added dropwise at -15°. After 5 minutes, a solution of 2.7 g of HCl.H-(D)Ala-Gly-OBzl and 1.3 ml of N-ethylmorpholine in 20 ml of DMF are added. After 1 hour's stirring at -10°, the mixture is worked up in the manner indicated under (c) above. The title compound is crystallised from methanol/petroleum ether. Decomp. 65°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04261888 |
| 出典データセット | uspto-grants-1981_04 |
| ORD ID | ord-528fd616dd3845aaa3779cd348d74a90 |
| 出典メモ | uspto-grants-1981_04 |