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HRID443918

反应详情

EQUATION

反应方程式

HRID 443918 的结构方程式

REACTANTS

反应物

6
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CCN1CCOCC1
HCID7525

N-Ethylmorpholine

C6H13NO

2 次

结构：CC(C)COC(=O)Cl
HCID62365

Isobutyl chloroformate

C5H9ClO2

结构：CC(C)(C)OC(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
HCID117439

BOC-L-tyrosine

C14H19NO5

结构：C[C@@H](N)C(=O)NCC(=O)OCc1ccccc1
HCID12800382

未命名化合物

结构：C[C@@H](NC(=O)OC(C)(C)C)C(=O)NCC(=O)OCc1ccccc1
HCID15567200

未命名化合物

PRODUCTS

生成物

1
结构：C[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)OC(C)(C)C)C(=O)NCC(=O)OCc1ccccc1
HCID15567201

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

2.8 g of Boc-Tyr-OH and 1.3 ml of N-ethylmorpholine are dissolved in 50 ml of absolute tetrahydrofuran and 1.3 ml of chloroformic acid iso-butyl ester are added dropwise at -15°. After 5 minutes, a solution of 2.7 g of HCl.H-(D)Ala-Gly-OBzl and 1.3 ml of N-ethylmorpholine in 20 ml of DMF are added. After 1 hour's stirring at -10°, the mixture is worked up in the manner indicated under (c) above. The title compound is crystallised from methanol/petroleum ether. Decomp. 65°.

WORKUP

后处理

  1. customThe title compound is crystallised from methanol/petroleum ether
  2. custom65°