Thionyl Chloride → 2,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid chloride

反応式

[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11](O)=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1.S(Cl)([Cl:17])=O>>[CH3:1][C:2]1([CH3:14])[C:6]2[CH:7]=[C:8]([C:11]([Cl:17])=[O:12])[CH:9]=[CH:10][C:5]=2[O:4][CH2:3]1

参加物

反応物 2

HCID 24386Thionyl Chloride

HCID 220413993,3-Dimethyl-2,3-dihydro-1-benzofuran-5-carboxylic acid

生成物 1

HCID 545007362,3-Dihydro-3,3-dimethylbenzofuran-5-carboxylic acid chloride収率 127.7%

実験手順

The product of stage (a) (3 g) was boiled under reflux in thionyl chloride (3.6 g) for 3 hours. Removal of the thionyl chloride under vacuum gave crude title product (4.2 g).

後処理

customRemoval of the thionyl chloride under vacuum

出典と根拠

ORDレコード: ord-e892632284b0435a993f4e96d43c9caf
出典データセット: uspto-grants-1981_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US04263037

反応ノート

読み込み中…