Sodium Hydroxide → Isobutylmalonic acid

HRID 444191

反応式

HRID 444191 の反応式
C([O:3][C:4]([CH:6]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:7]([O:9]CC)=[O:8])=[O:5])C.[OH-].[Na+]>CO>[C:7]([CH:6]([CH2:12][CH:13]([CH3:15])[CH3:14])[C:4]([OH:5])=[O:3])([OH:9])=[O:8]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 25047Diethyl isobutylmalonate

生成物 1

HCID 78069Isobutylmalonic acid収率 100.2%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 91.1 g of 2-(ethyloxycarbonyl)-4-methylpentanoic acid, ethyl ester in 300 ml of methanol is treated for 6 hours at 80° C. with 400 ml of 10% sodium hydroxide. The solution is concentrated in vacuo to 400 ml and acidified with 10% hydrochloric acid. The product is extracted with ethyl acetate to yield 67.6 g of the title compound, which crystallizes on standing. Recrystallization from ethyl acetate-hexane yields the title compound, melting point 102°-105° C.

後処理

  1. concentrationThe solution is concentrated in vacuo to 400 ml
  2. extractionThe product is extracted with ethyl acetate

出典と根拠

ORDレコード
ord-aba4e87484d749a19d784f4fd13ccc12
出典データセット
uspto-grants-1981_04
特許番号
US04263293

関連ノート

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