Hydrochloric Acid → 9-Chloro-9-(4-diethylaminophenyl)-10-phenylacridan

HRID 444297ノート

反応式

HRID 444297 の反応式
[CH2:1]([N:3]([CH2:32][CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2(OC)[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:6][CH:5]=1)[CH3:2].[ClH:34]>O1CCCC1>[CH2:1]([N:3]([CH2:32][CH3:33])[C:4]1[CH:9]=[CH:8][C:7]([C:10]2([Cl:34])[C:23]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[N:17]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[C:16]3[C:11]2=[CH:12][CH:13]=[CH:14][CH:15]=3)=[CH:6][CH:5]=1)[CH3:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 13014081HCID 13014081、化合物

生成物 1

HCID 934619-Chloro-9-(4-diethylaminophenyl)-10-phenylacridan収率 95.8%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

9(p-Diethylaminophenyl)-9-methoxy-10-phenylacridan (12.0 g, 0.0276 mole) is slurried in 150 ml of tetrahydrofuran while anhydrous hydrogen chloride is bubbled in with cooling. The hydrogen chloride is bubbled in until the slurry reaches a pH of 1.0 and a bright yellow color is obtained. The product is collected on a Buchner funnel, washed twice with 10 ml portions of tetrahydrofuran and dried at 50° C. to give 11.6 g (95.8% yield) of 9(p-diethylaminophenyl)-9-chloro-10-phenylacridan.

後処理

  1. customis bubbled in
  2. temperaturewith cooling
  3. customThe hydrogen chloride is bubbled in until the slurry
  4. customa bright yellow color is obtained
  5. customThe product is collected on a Buchner funnel
  6. washwashed twice with 10 ml portions of tetrahydrofuran
  7. customdried at 50° C.

出典と根拠

ORDレコード
ord-41c6b5d04df84e44ab94536377e050ce
出典データセット
uspto-grants-1981_04
特許番号
US04263398

反応ノート

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