N-[3-(bromoacetyl)phenyl]hexadecane-1-sulfonamide → Saccharin
反応式
[S:1]1([C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:5](=[O:6])[NH:4]1)(=[O:3])=[O:2].[Na].C(S(NC1C=C(C(=O)CBr)C=CC=1)(=O)=O)CCCCCCCCCCCCCCC>CN(C)C=O.[Cl-].[Na+].O>[S:1]1([C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:5](=[O:6])[NH:4]1)(=[O:2])=[O:3]参加物
5
実験手順
A mixture of 4.5 g of sodium saccharin and 10 g of the product of Step B in 70 ml of dimethylformamide was stirred overnight at ambient temperature. The reaction mixture was poured in brine and icy water (about 600 ml) and the precipirated product was filtered, and recrystallized from 200 ml of methanol to give 12 g (100%) of Compound 24: mp 85.9° .
後処理
- filtrationicy water (about 600 ml) and the precipirated product was filtered
- customrecrystallized from 200 ml of methanol
出典と根拠
- ORDレコード
- ord-511671a1512749448237ccf69a401d04
- 出典データセット
- uspto-grants-1981_04
- 特許番号
- US04263393
反応ノート
読み込み中…