Chlorotrimethylsilane → 2-(2-Acetoxy-3-chloro-propoxy)-3-methoxy-pyridine
反応式
C[Si](C)(C)[Cl:3].C([O:8][C:9]1([CH3:24])O[CH2:12][CH:11]([CH2:14][O:15][C:16]2[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[CH:18][N:17]=2)[O:10]1)C>C(Cl)Cl>[C:9]([O:10][CH:11]([CH2:12][Cl:3])[CH2:14][O:15][C:16]1[C:21]([O:22][CH3:23])=[CH:20][CH:19]=[CH:18][N:17]=1)(=[O:8])[CH3:24]参加物
4
実験手順
45 ml of trimethylchlorosilane are added to a mixture of 85 g of 2-ethoxy-5-(3-methoxy-2-pyridyloxymethyl)-2-methyl-1,3-dioxolane in 500 ml of methylene chloride and the mixture is stirred for one hour at 20°-30°. Complete evaporation under reduced pressure yields crude 2-(2-acetoxy-3-chloro-propoxy)-3-methoxy-pyridine in the form of an oil, which is used without purification.
後処理
- customComplete evaporation under reduced pressure
出典と根拠
- ORDレコード
- ord-7954d72259c94326a872eba2df1e1d41
- 出典データセット
- uspto-grants-1981_04
- 特許番号
- US04264599
反応ノート
読み込み中…