Lithium Hydroxide → 6-[(4-Chlorophenyl)sulfanyl]-3-pyridinylamine

HRID 444462ノート

反応式

HRID 444462 の反応式
Cl[C:2]1[N:7]=[CH:6][C:5]([N+:8]([O-])=O)=[CH:4][CH:3]=1.[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([SH:18])=[CH:14][CH:13]=1.[OH-].[Li+]>CN(C=O)C>[Cl:11][C:12]1[CH:17]=[CH:16][C:15]([S:18][C:2]2[N:7]=[CH:6][C:5]([NH2:8])=[CH:4][CH:3]=2)=[CH:14][CH:13]=1

参加物

5

反応物 3

HCID 3939Lithium HydroxideHCID 7815p-ChlorothiophenolHCID 783082-Chloro-5-nitropyridine

生成物 1

HCID 28001276-[(4-Chlorophenyl)sulfanyl]-3-pyridinylamine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

6-Chloro-3-nitropyridine (54.5 grams), 4-chlorothiophenol (50.0 grams), and lithium hydroxide (12.5 grams) were mixed in about 500 ml. of DMF and stirred overnight (about 18 hours) at room temperature. The reaction mixture was poured into ice-water, filtered, and the separated product washed three times with water and air dried, yield, 100 grams.

後処理

  1. filtrationfiltered
  2. washthe separated product washed three times with water and air
  3. customdried
  4. customyield

出典と根拠

ORDレコード
ord-f815efe19f0e4996899da64acd82ac39
出典データセット
uspto-grants-1981_04
特許番号
US04264605

反応ノート

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