Ammonium Chloride → 5-[(4-Chlorophenyl)sulfanyl]pyridin-2-amine
反応式
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:6][N:5]=1)([O-])=O.[Cl-].[NH4+]>[Fe]>[NH2:1][C:4]1[CH:9]=[CH:8][C:7]([S:10][C:11]2[CH:16]=[CH:15][C:14]([Cl:17])=[CH:13][CH:12]=2)=[CH:6][N:5]=1参加物
4
実験手順
2-Nitro-5-(4-chlorophenylthio)pyridine (10.5 grams), ammonium chloride (50.0 grams), and powdered iron (30.0 grams) were reacted in the same procedures reported in Example 3. The reaction mixture was filtered hot solvents were removed. The product was extracted with ethyl acetate, washed with water, the ethyl acetate removed, and the product crystallized from ethyl acetate-hexanes, yield 4.5 grams, m.p. 157°-159° C.
後処理
- filtrationThe reaction mixture was filtered hot solvents
- customwere removed
- extractionThe product was extracted with ethyl acetate
- washwashed with water
- customthe ethyl acetate removed
- customthe product crystallized from ethyl acetate-hexanes, yield 4.5 grams, m.p. 157°-159° C.
出典と根拠
- ORDレコード
- ord-2f8ea697d9d74a2d80506e9342fd4fca
- 出典データセット
- uspto-grants-1981_04
- 特許番号
- US04264605
反応ノート
読み込み中…