Dimethyl Sulfate → HCID 20515167、化合物

HRID 444571ノート

反応式

HRID 444571 の反応式
[SH:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1.[OH-].[Na+].S(OC)(O[CH3:27])(=O)=O>O>[CH3:27][S:1][C:2]1[CH:3]=[C:4]([C:14](=[O:20])[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:5]=[CH:6][C:7]=1[CH:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH2:9]1

参加物

5

反応物 3

HCID 6497Dimethyl SulfateHCID 14798Sodium HydroxideHCID 20515146Ethyl 3-mercapto-4-cyclohexylphenylglyoxylate

生成物 1

HCID 20515167HCID 20515167、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
40 °C

実験手順

To 3.85 g. of ethyl 3-mercapto-4-cyclohexylphenylglyoxylate in 40 ml. of water containing 0.65 g. of sodium hydroxide is added 2 ml. of dimethyl sulfate with stirring. The reaction mixture is gradually warmed to 40° C. and stirred for 2 hours. The mixture is cooled and extracted with ether which is washed with water, dried and evaporated in vacuo. The residue is distilled to obtain ethyl 3-methylthio-4-cyclohexylphenylglyoxylate.

後処理

  1. temperatureThe mixture is cooled
  2. extractionextracted with ether which
  3. washis washed with water
  4. customdried
  5. customevaporated in vacuo
  6. distillationThe residue is distilled

出典と根拠

ORDレコード
ord-958f134ae3c840f3a993046784da189b
出典データセット
uspto-grants-1981_04
特許番号
US04264627

反応ノート

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