Tetrabutylammonium Fluoride → 1068560-15-5

HRID 444895ノート

反応式

HRID 444895 の反応式
[F-:1].C([N+](CCCC)(CCCC)CCCC)CCC.[CH3:19][O:20][C:21](=[O:34])[C:22]([CH3:33])([CH3:32])[CH2:23]OS(C(F)(F)F)(=O)=O>C1COCC1>[CH3:19][O:20][C:21](=[O:34])[C:22]([CH3:33])([CH3:32])[CH2:23][F:1]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 574170981163707-68-3

生成物 1

HCID 597024501068560-15-5

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

27 mL of a 1 M solution of tetrabutylammonium fluoride in THF are added slowly and under ice cooling to a solution of 7.25 g (27.4 mmol) 2,2-dimethyl-3-trifluoromethanesulfonyloxy-propionic acid methyl ester in 150 mL of THF. The resulting solution is stirred 6 h at 0° C. and then 10 h at RT. The solvent is evaporated carefully and the residue partitioned between DCM and brine. The organic phase is washed with brine, dried with sodium sulfate and evaporated carefully. The brown oil is distilled in a Kugelrohr-oven (oven temperature 120 to 150° C.) to give the title compound as a colorless liquid.

後処理

  1. custom10 h
  2. customat RT
  3. customThe solvent is evaporated carefully
  4. customthe residue partitioned between DCM and brine
  5. washThe organic phase is washed with brine
  6. dry with materialdried with sodium sulfate
  7. customevaporated carefully
  8. distillationThe brown oil is distilled in a Kugelrohr-oven (oven temperature 120 to 150° C.)

出典と根拠

ORDレコード
ord-11b6d24494344cf79cc2eccfc1a65731
出典データセット
uspto-grants-2013_07
特許番号
US08476268B2

反応ノート

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