関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Diisopropylamine | HCID 7912 | — |
| 反応物 | Hexadecanedioic acid | HCID 10459 | — |
| 反応物 | 4-Methyloxybenzyl chloride | HCID 69993 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 生成物 | Hexadecanedioic acid mono-(4-methoxy-benzyl)ester | HCID 58079476 | — |
反応手順
Hexadecandioic acid (2 g, 7 mmol) was dissolved in dry NMP (25 mL). Diisopropylamin (1.2 mL, 7 mmol) and 4-methoxybenzyl chloride (0.95 mL, 7 mmol) was added, followed by NaI (0.52 g, 3.5 mmol). The mixture was heated to 80° C. for 1 hour, poured into water (100 mL) and filtered. The precipate was washed with dichloromethane (150 mL), the dichoromethane phase was dried (Na2SO4) and solvent removed in vacuo to yield the crude product, which was recrystalized several times from heptane to yield hexadecanedioic acid mono-(4-methoxy-benzyl) ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08476228B2 |
|---|
| 出典データセット | uspto-grants-2013_07 |
|---|
| ORD ID | ord-d56b3bbfe0984fc58760dd7d3d47ace5 |
|---|
| 出典メモ | uspto-grants-2013_07 |
|---|
