反应详情

温度

80 °C

Hexadecandioic acid (2 g, 7 mmol) was dissolved in dry NMP (25 mL). Diisopropylamin (1.2 mL, 7 mmol) and 4-methoxybenzyl chloride (0.95 mL, 7 mmol) was added, followed by NaI (0.52 g, 3.5 mmol). The mixture was heated to 80° C. for 1 hour, poured into water (100 mL) and filtered. The precipate was washed with dichloromethane (150 mL), the dichoromethane phase was dried (Na2SO4) and solvent removed in vacuo to yield the crude product, which was recrystalized several times from heptane to yield hexadecanedioic acid mono-(4-methoxy-benzyl) ester.

1. filtrationfiltered
2. washThe precipate was washed with dichloromethane (150 mL)
3. dry with materialthe dichoromethane phase was dried (Na2SO4) and solvent
4. customremoved in vacuo
5. customto yield the crude product, which
6. customwas recrystalized several times from heptane