4-Nitrophenyl chloroformate → 4-Nitrophenyl pyrimidin-5-ylcarbamate

HRID 445281

反応式

HRID 445281 の反応式
[N:1]1[CH:6]=[C:5]([NH2:7])[CH:4]=[N:3][CH:2]=1.Cl[C:9]([O:11][C:12]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][CH:13]=1)=[O:10]>N1C=CC=NC=1>[N:1]1[CH:6]=[C:5]([NH:7][C:9](=[O:10])[O:11][C:12]2[CH:13]=[CH:14][C:15]([N+:18]([O-:20])=[O:19])=[CH:16][CH:17]=2)[CH:4]=[N:3][CH:2]=1

参加物

4

反応物 2

HCID 821294-Nitrophenyl chloroformateHCID 344373Pyrimidin-5-amine

生成物 1

HCID 595363234-Nitrophenyl pyrimidin-5-ylcarbamate

試薬・触媒・溶媒 1

HCID 9260Pyrimidine溶媒

実験手順

To a solution of pyrimidin-5-amine (190 mg, 2.0 mmol) in pyrimidine (3 mL) was added 4-nitrophenyl chloroformate (403 mg, 2.0 mmol). The resulting mixture was stirred at RT overnight, and then heated to 60° C. overnight. After cooling to RT, the solvent was removed under vacuum to give the title compound as a brown solid, which was used in the next step without further purification. MS (ESI, positive ion) m/z: 261 (M+H).

後処理

  1. temperatureheated to 60° C. overnight
  2. temperatureAfter cooling to RT
  3. customthe solvent was removed under vacuum

出典と根拠

ORDレコード
ord-530f5a4e0e484b498192709ca5422fbb
出典データセット
uspto-grants-2013_07
特許番号
US08476297B2

関連ノート

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