Methanol → HCID 59536363、化合物

HRID 445303

反応式

HRID 445303 の反応式
Cl.[F:2][C:3]1([F:10])[CH2:8][CH2:7][CH:6]([NH2:9])[CH2:5][CH2:4]1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][C:18]([N+:21]([O-:23])=[O:22])=[CH:17][CH:16]=1)=[O:13].CCN(C(C)C)C(C)C.CO>C(Cl)Cl>[F:2][C:3]1([F:10])[CH2:8][CH2:7][CH:6]([NH:9][C:12](=[O:13])[O:14][C:15]2[CH:16]=[CH:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=2)[CH2:5][CH2:4]1

参加物

6

反応物 4

HCID 887MethanolHCID 81531DiisopropylethylamineHCID 821294-Nitrophenyl chloroformateHCID 231506694,4-Difluorocyclohexan-1-amine hydrochloride

生成物 1

HCID 59536363HCID 59536363、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of 4,4-difluorocyclohexanamine hydrochloride (Matrix scientific, 250 mg, 1.45 mmol) in DCM (5 mL) was added 4-nitrophenyl chloroformate (367 mg, 1.82 mmol) and DIEA (507 μl, 0.29 mmol). The resulting mixture was then stirred at RT for 16 h. Then, MeOH (2 mL) was added and the solvents were removed. The residue was purified by silica gel flash column chromatography (0%-100% EtOAc/hexane) to give the title compound as a yellow solid.

後処理

  1. customthe solvents were removed
  2. customThe residue was purified by silica gel flash column chromatography (0%-100% EtOAc/hexane)

出典と根拠

ORDレコード
ord-00c2f84f8c2b42dca18083329f211cb5
出典データセット
uspto-grants-2013_07
特許番号
US08476297B2

関連ノート

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