Methanol → HCID 59619635、化合物

HRID 445653ノート

反応式

HRID 445653 の反応式
[Na].Cl[C:3]1[C:8]([O:9][CH:10]([CH3:12])[CH3:11])=[CH:7][CH:6]=[CH:5][N:4]=1.[CH3:13][OH:14]>>[CH:10]([O:9][C:8]1[C:3]([O:14][CH3:13])=[N:4][CH:5]=[CH:6][CH:7]=1)([CH3:12])[CH3:11]

参加物

4

反応物 3

HCID 887Methanol2 回HCID 5360545SodiumHCID 336790892-Chloro-3-[(propan-2-yl)oxy]pyridine

生成物 1

HCID 59619635HCID 59619635、化合物

反応条件

温度
150 °C

実験手順

To a solution of methanolate obtained by dissolving sodium (534 mg, 23.25 mmol) in MeOH (8 ml) was added a solution of 2-chloro-3-isopropoxy-pyridine (Stage 93.1.4, 1.14 g, 6.64 mmol) in MeOH (2 ml). The reaction mixture was heated at 150° C. by microwave irradiation for 25 min then concentrated and quenched with EtOAc and brine. The organic layer was dried over Na2SO4, filtered and evaporated to give the title compound as an oil (HPLC: tR 2.66 min (Method A); M+H=264 MS-ES)

後処理

  1. concentrationthen concentrated
  2. customquenched with EtOAc and brine
  3. dry with materialThe organic layer was dried over Na2SO4
  4. filtrationfiltered
  5. customevaporated

出典と根拠

ORDレコード
ord-53667973c7e14d1eab3e41913cde97bb
出典データセット
uspto-grants-2013_07
特許番号
US08476294B2

反応ノート

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