Thionyl Chloride → 5-chloro-7-(chloromethyl)-2,2-dimethylbenzofuran-3(2H)-one

HRID 445837ノート

反応式

HRID 445837 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:14]O)[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[C:7](=[O:12])[C:6]=2[CH:13]=1.S(Cl)([Cl:18])=O>>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:14][Cl:18])[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[C:7](=[O:12])[C:6]=2[CH:13]=1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 585665785-chloro-7-(hydroxymethyl)-2,2-dimethylbenzofuran-3(2H)-one

生成物 1

HCID 585667245-chloro-7-(chloromethyl)-2,2-dimethylbenzofuran-3(2H)-one

実験手順

A solution of 5-chloro-7-(hydroxymethyl)-2,2-dimethylbenzofuran-3(2H)-one (656) (278 mg, 1.23 mmol) in neat thionyl chloride (5 mL) was stirred at room temperature for 48 hours. The reaction was concentrated to obtain 5-chloro-7-(chloromethyl)-2,2-dimethylbenzofuran-3(2H)-one (657) as a brown/grey solid.

後処理

  1. concentrationThe reaction was concentrated

出典と根拠

ORDレコード
ord-4e4da32f124e401da38ae1403aa19617
出典データセット
uspto-grants-2013_07
特許番号
US08476308B2

反応ノート

読み込み中…