Thionyl Chloride → 5-Bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran

HRID 445845ノート

反応式

HRID 445845 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:13]O)[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[CH:12]=1.S(Cl)([Cl:17])=O>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([CH2:13][Cl:17])[C:5]2[O:9][C:8]([CH3:11])([CH3:10])[CH2:7][C:6]=2[CH:12]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 58566787(5-Bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methanol

生成物 1

HCID 585664675-Bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of (5-bromo-2,2-dimethyl-2,3-dihydrobenzofuran-7-yl)methanol (669) (390 mg, 1.51 mmol) in dichloromethane (15 mL) was added thionyl chloride (0.56 mL, 7.58 mmol). The reaction was stirred at room temperature for 2 hours and then concentrated to afford 5-bromo-7-(chloromethyl)-2,2-dimethyl-2,3-dihydrobenzofuran (670).

後処理

  1. concentrationconcentrated

出典と根拠

ORDレコード
ord-467e62797f3d4018addc481f7913fce1
出典データセット
uspto-grants-2013_07
特許番号
US08476308B2

反応ノート

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