Ethanol → Sri 62320

HRID 445945

反応式

HRID 445945 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([CH:17]([CH3:19])[CH3:18])[C:9]=2/[CH:20]=[CH:21]/[C@@H:22]([OH:30])[CH2:23][C@@H:24]([OH:29])[CH2:25][C:26]([OH:28])=[O:27])=[CH:4][CH:3]=1.CO[N-]C.C(O)C.[OH-].[Na+:39]>O>[Na+:39].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]([CH:17]([CH3:19])[CH3:18])[C:9]=2/[CH:20]=[CH:21]/[C@@H:22]([OH:30])[CH2:23][C@@H:24]([OH:29])[CH2:25][C:26]([O-:28])=[O:27])=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 131730686HCID 131730686、化合物

生成物 1

HCID 23663976Sri 62320収率 87%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

E-(7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-[(3R,5S)-3,5-dihydroxy-hept-6-enoic acid])-N-methoxy-N-methyl-amide (3.0 g), ethyl alcohol (30.0 mL), and a solution of sodium hydroxide (0.4 g) in water (3.0 mL) were added to a reactor. The reaction mixture was stirred for 16 hours while maintaining the temperature of 20˜25° C. and then concentrated under reduced pressure. The resulting residue was dissolved in chloroform (10.0 mL) and then diethyl ether (100.0 mL) was added thereto. The reaction mixture was stirred for over 5 hours and then filtered under reduced pressure. The resulting white solid was dried under vacuum to obtain (3R,5S,6E)-7-[3-(4-fluorophenyl)-1-isopropyl-1H-indol-2-yl]-3,5-dihydroxy hept-6-enoic acid sodium salt (2.4 g, yield 85%).

後処理

  1. temperaturewhile maintaining the temperature of 20˜25° C.
  2. concentrationconcentrated under reduced pressure
  3. dissolutionThe resulting residue was dissolved in chloroform (10.0 mL)
  4. additiondiethyl ether (100.0 mL) was added
  5. stirringThe reaction mixture was stirred for over 5 hours
  6. filtrationfiltered under reduced pressure
  7. customThe resulting white solid was dried under vacuum

出典と根拠

ORDレコード
ord-da2bd667ad9c4b65b43a6b634f1de1b4
出典データセット
uspto-grants-2013_07
特許番号
US08476432B2

関連ノート

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