tert-Butyl 2-[(3R*,4S*)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate → tert-Butyl 2-[(3R*,4S*)-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

HRID 446030ノート

反応式

HRID 446030 の反応式
ClC1C=CC=C(Cl)C=1C[N:10]1[CH2:14][C@@H:13]([CH3:15])[C@@:12]([CH2:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])([C:16](=[O:30])[NH:17][CH:18]2[CH2:23][CH2:22][N:21]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH3:29])[CH2:20][CH2:19]2)[CH2:11]1>[OH-].[Pd+2].[OH-].CO>[CH2:24]([N:21]1[CH2:20][CH2:19][CH:18]([NH:17][C:16]([C@:12]2([CH2:31][C:32]([O:34][C:35]([CH3:37])([CH3:36])[CH3:38])=[O:33])[C@H:13]([CH3:15])[CH2:14][NH:10][CH2:11]2)=[O:30])[CH2:23][CH2:22]1)[CH2:25][CH2:26][CH2:27][CH2:28][CH3:29]

参加物

4

反応物 1

HCID 71293842tert-Butyl 2-[(3R*,4S*)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate

生成物 1

HCID 71293828tert-Butyl 2-[(3R*,4S*)-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate収率 100%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 887Methanol溶媒

実験手順

Methanol (10 ml) and 20% palladium hydroxide (50 mg) were added to 250 mg of tert-butyl 2-[(3R*,4S*)-1-[(2,6-dichlorophenyl)methyl]-3-[(1-hexylpiperidin-4-yl)carbamoyl]-4-methylpyrrolidin-3-yl]acetate obtained in Example 10h, followed by stirring at room temperature for two hours under a hydrogen atmosphere. The reaction mixture was filtered, and the filtrate was concentrated to give the title compound (180 mg).

後処理

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-0805993024fb47208219682df3b1a16c
出典データセット
uspto-grants-2013_07
特許番号
US08476301B2

反応ノート

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