反応式
[CH2:1]([Sn:5]([CH2:23][CH2:24][CH2:25][CH3:26])([CH2:19][CH2:20][CH2:21][CH3:22])[C:6]1[CH:7]=[C:8]([C:12]2[O:16][C:15]([CH:17]=O)=[CH:14][CH:13]=2)[CH:9]=[CH:10][CH:11]=1)[CH2:2][CH2:3][CH3:4].[CH2:27]([O:29][C:30](=[O:39])[CH2:31][N:32]1[C:36](=[O:37])[CH2:35][S:34][C:33]1=[S:38])[CH3:28].N1CCCCC1>ClCCl>[CH2:27]([O:29][C:30](=[O:39])[CH2:31][N:32]1[C:36](=[O:37])/[C:35](=[CH:17]/[C:15]2[O:16][C:12]([C:8]3[CH:9]=[CH:10][CH:11]=[C:6]([Sn:5]([CH2:1][CH2:2][CH2:3][CH3:4])([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:19][CH2:20][CH2:21][CH3:22])[CH:7]=3)=[CH:13][CH:14]=2)/[S:34][C:33]1=[S:38])[CH3:28]参加物
5
反応条件
- 温度
- 25 °C
実験手順
5-(3-(Tributylstannyl)phenyl)furan-2-carbaldehyde (7 mg, 0.015 mmol) and ethyl-2-(4-oxo-2-thioxothiazolidin-3-yl)acetate (3.5 mg, 0.016 mmol) synthesized by the same method as in Example 1 were dissolved in dichloromethane (2 mL), piperidine (5 μL) was added thereto, and the mixture was stirred at room temperature (25° C.) overnight. After the reaction was completed the solvent was removed by evaporation under reduced pressure, and the residue was subjected to silica gel column chromatography using ethyl acetate/hexane (3/7 (volume ratio)) as an eluent, to give labeling precursor 1 in a yield of 6 mg (yield 56.6%).
後処理
- customwas removed by evaporation under reduced pressure
- customto give labeling precursor 1 in a yield of 6 mg (yield 56.6%)
出典と根拠
- ORDレコード
- ord-fbcfd2c03e5349f0a8dec5638b4a4d2e
- 出典データセット
- uspto-grants-2013_07
- 特許番号
- US08476449B2
関連ノート
読み込み中…