Potassium Carbonate → 2-Cyano-6-benzyloxymethyl quinoline

HRID 446188

反応式

HRID 446188 の反応式
[C:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8](O)[CH:9]=2)[N:4]=1)#[N:2].C(=O)([O-])[O-].[K+].[K+].Cl[CH2:21][O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CC(C)=O>[C:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH2:21][O:22][CH2:23][C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)[CH:9]=2)[N:4]=1)#[N:2]

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 137983Benzyl chloromethyl etherHCID 144295346-Hydroxyquinoline-2-carbonitrile

生成物 1

HCID 668385032-Cyano-6-benzyloxymethyl quinoline

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

To a solution of 2-cyano-6-hydroxyquinoline (100 mg) in 10 mL of acetone was added potassium carbonate (122 mg). After stirring at RT for three minutes, the solution was put on ice. Benzyl chloromethyl ether (122 μL) was added through a needle and the resultant solution was stirred on ice for 2 hours. The solvent was then removed under vacuum and the residue was purified by flash chromatography with dichloromethane. 157 mg was obtained.

後処理

  1. customThe solvent was then removed under vacuum
  2. customthe residue was purified by flash chromatography with dichloromethane
  3. custom157 mg was obtained

出典と根拠

ORDレコード
ord-392a545e01d546d7b058c2fce200b8f5
出典データセット
uspto-grants-2013_07
特許番号
US08476450B2

関連ノート

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