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Methanol → HCID 58168614、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methanol | HCID 887 | — |
| 反応物 | (But-3-yn-1-yloxy)(tert-butyl)dimethylsilane | HCID 4304567 | — |
| 反応物 | 3-(3-(Hydroxymethyl)phenyl)propan-1-ol | HCID 55267680 | — |
| 溶媒 | Ammonia | HCID 222 | — |
| 生成物 | HCID 58168614 | HCID 58168614 | — |
反応手順
Prepared by the method of Aromatic Intermediate 18, step a using tert-butyldimethyl(but-3-ynyloxy)silane (0.92 g) in place of tert-butyl dimethyl(prop-2-ynyloxy)silane. The preparative HPLC conditions were changed to XBridge™, Gradient: 75-99% methanol in 0.2% aqueous ammonia to avoid cleavage of the silyl protecting group. Yield 0.79 g.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08476265B2 |
| 出典データセット | uspto-grants-2013_07 |
| ORD ID | ord-85e26b7b53604333b61856bee59e2fbd |
| 出典メモ | uspto-grants-2013_07 |