Ammonium Chloride → 4-(4-Tert-butylpiperazin-1-yl)aniline
反応式
[C:1]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:16]=[CH:15][C:14]([N+:17]([O-])=O)=[CH:13][CH:12]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:3])[CH3:2].[Cl-].[NH4+]>CO.O.[Fe]>[C:1]([N:5]1[CH2:10][CH2:9][N:8]([C:11]2[CH:12]=[CH:13][C:14]([NH2:17])=[CH:15][CH:16]=2)[CH2:7][CH2:6]1)([CH3:4])([CH3:2])[CH3:3]参加物
6
実験手順
To a solution of 840 mg (3.189 mmol) of 1-tert-butyl-4-(4-nitrophenyl)piperazine in 24 mL of methanol, 904 mg (16.9 mmol) of ammonium chloride dissolved in 6 mL of water and 552 mg (9.886 mmol) of iron were added. After 7 hours, the suspension was cooled and filtered. pH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase. Extraction with dichloromethane yielded 667 mg of the title amine.
後処理
- temperaturethe suspension was cooled
- filtrationfiltered
- additionpH was adjusted to 10 through portionwise addition of Na2CO3 to the aqueous phase
- extractionExtraction with dichloromethane
出典と根拠
- ORDレコード
- ord-e7e685d6fe9e494f97c7dc5fcc2eda18
- 出典データセット
- uspto-grants-2013_09
- 特許番号
- US08541429B2
反応ノート
読み込み中…