Diisopropylethylamine → N-Butyl-N-(2,2-dimethoxyethyl)-3-(3-(2-(4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanamide

反応式

[CH:1]([C:4]1[S:5][CH:6]=[C:7]([C:9]([N:11]2[CH2:16][C:15]3([CH2:21][CH2:20][N:19]([CH2:22][CH2:23][C:24]4[CH:25]=[C:26]([CH:35]=[CH:36][CH:37]=4)[CH2:27][CH2:28][O:29][CH2:30][CH2:31][C:32](O)=[O:33])[CH2:18][CH2:17]3)[O:14][CH2:13][CH2:12]2)=[O:10])[N:8]=1)([CH3:3])[CH3:2].CCN(C(C)C)C(C)C.[CH3:47][O:48][CH:49]([O:56][CH3:57])[CH2:50][NH:51][CH2:52][CH2:53][CH2:54][CH3:55].CN(C(ON1N=NC2C=CC=NC1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F>ClCCl.O>[CH2:52]([N:51]([CH2:50][CH:49]([O:48][CH3:47])[O:56][CH3:57])[C:32](=[O:33])[CH2:31][CH2:30][O:29][CH2:28][CH2:27][C:26]1[CH:35]=[CH:36][CH:37]=[C:24]([CH2:23][CH2:22][N:19]2[CH2:20][CH2:21][C:15]3([O:14][CH2:13][CH2:12][N:11]([C:9]([C:7]4[N:8]=[C:4]([CH:1]([CH3:2])[CH3:3])[S:5][CH:6]=4)=[O:10])[CH2:16]3)[CH2:17][CH2:18]2)[CH:25]=1)[CH2:53][CH2:54][CH3:55]

参加物

実験手順

3-(3-(2-(4-(2-Isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)ethyl)phenethoxy)propanoic acid [Example 34, step c] (0.50 g), Hunig's base (0.58 mL), and N-(2,2-dimethoxyethyl)butan-1-amine [J. Am. Chem. Soc. 1949, 71(6), 2272] (0.12 g) were dissolved in dichloromethane (10 mL). HATU (0.33 g) was then added and the mixture was stirred at room temperature for 24 hours. The mixture was poured into water and extracted with dichloromethane. The organic extracts were combined and evaporated under reduced pressure to give the subtitled compound. Yield 0.45 g.

後処理

extractionextracted with dichloromethane
customevaporated under reduced pressure

出典と根拠

ORDレコード: ord-b2c6913556bf402aabfcc2ce98f026ae
出典データセット: uspto-grants-2013_07
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08476265B2

反応ノート

読み込み中…

反応式

参加物

反応物 4

生成物 1

試薬・触媒・溶媒 2

実験手順

後処理

出典と根拠

反応ノート