Hydrochloric Acid → 2-({6-[(2-{4-[(Biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid

HRID 446620ノート

反応式

HRID 446620 の反応式
[OH-].[Na+].C([C:5]1[N:6]=[C:7]([NH:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([N:21]([CH2:23][CH2:24][N:25]2[CH2:30][CH2:29][CH:28]([O:31][C:32](=[O:46])[NH:33][C:34]3[CH:39]=[CH:38][CH:37]=[CH:36][C:35]=3[C:40]3[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=3)[CH2:27][CH2:26]2)[CH3:22])=[O:20])[S:8][C:9]=1[C:10]([OH:12])=[O:11])C.Cl>C(O)C>[C:35]1([C:40]2[CH:41]=[CH:42][CH:43]=[CH:44][CH:45]=2)[CH:36]=[CH:37][CH:38]=[CH:39][C:34]=1[NH:33][C:32]([O:31][CH:28]1[CH2:27][CH2:26][N:25]([CH2:24][CH2:23][N:21]([CH3:22])[C:19](=[O:20])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][C:7]2[S:8][C:9]([C:10]([OH:12])=[O:11])=[CH:5][N:6]=2)[CH2:30][CH2:29]1)=[O:46]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 86663484Ethyl 2-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid

生成物 1

HCID 866634832-({6-[(2-{4-[(Biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A 10 N aqueous sodium hydroxide solution (27 μL) was added to a solution of the compound obtained in Example 104a in ethanol (3.0 mL), and the mixture was stirred at room temperature for 16 hours. The mixture was ice cooled, then a 6 N aqueous hydrochloric acid solution (453 μL, 1) was added, and then the solvent was evaporated under reduced pressure. Methanol (2 mL) and toluene (10 mL) were added to the residue, and the solvent was evaporated under reduced pressure again to give crude 2-({6-[(2-{4-[(biphenyl-2-ylcarbamoyl)oxy]piperidin-1-yl}ethyl)(methyl)amino]-6-oxohexyl}amino)-1,3-thiazole-5-carboxylic acid (357 mg).

後処理

  1. temperaturecooled
  2. customthe solvent was evaporated under reduced pressure
  3. additionMethanol (2 mL) and toluene (10 mL) were added to the residue
  4. customthe solvent was evaporated under reduced pressure again

出典と根拠

ORDレコード
ord-f4372ce8f5b14f4480c4e8439ff6ee3c
出典データセット
uspto-grants-2013_07
特許番号
US08476253B2

反応ノート

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