(6-Methylpyridin-2-yl)methanol hydrochloride → 2-(Chloromethyl)-6-methylpyridine

HRID 446816

反応式

HRID 446816 の反応式
[ClH:1].[CH3:2][C:3]1[N:8]=[C:7]([CH2:9]O)[CH:6]=[CH:5][CH:4]=1>O=S(Cl)Cl>[Cl:1][CH2:9][C:7]1[CH:6]=[CH:5][CH:4]=[C:3]([CH3:2])[N:8]=1

参加物

3

反応物 1

HCID 18413908(6-Methylpyridin-2-yl)methanol hydrochloride

生成物 1

HCID 765462-(Chloromethyl)-6-methylpyridine収率 70.6%

試薬・触媒・溶媒 1

HCID 24386Thionyl Chloride溶媒

実験手順

A solution of (6-methylpyridin-2-yl)methanol hydrochloride (1.0 g, 0.008 mol) in SOCl2 (3 mL) was stirred at RT for 1 h. The reaction mixture was then concentrated in vacuo to obtain the crude product. The crude material was azeotroped with toluene and the resulting residue was filtered and dried in vacuo to afford 2-(chloromethyl)-6-methylpyridine (800 mg, 63%) as a light brown solid.

後処理

  1. concentrationThe reaction mixture was then concentrated in vacuo
  2. customto obtain the crude product
  3. customThe crude material was azeotroped with toluene
  4. filtrationthe resulting residue was filtered
  5. customdried in vacuo

出典と根拠

ORDレコード
ord-d56dcbc7c9984717852394e78b9c4ed7
出典データセット
uspto-grants-2013_07
特許番号
US08481534B2

関連ノート

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